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Biochemistry and Molecular Biology, Faculty of Medicine

BIOC: Biochemistry

BIOC 202 (3) Introductory Medical Biochemistry
Introduction to proteins and enzymes, carbohydrate metabolism, and glucose homeostasis. The course emphasis is on human biochemistry and it is designed for students going into health science fields. Credit will be granted for only one of BIOC 202, BIOC 203 or BIOL 201. [3-0-0]
Prerequisite: Either (a) CHEM 203 or (b) CHEM 233 or (c) all of CHEM 233, PHAR 220. For option (a), a corequisite of CHEM 213 is required. For option (b), a corequisite of CHEM 205 is required.
Equivalency: BIOC 202, BIOC 203, BIOL 201.
BIOC 203 (3) Fundamentals of Biochemistry
Amino acids and proteins. Enzymes and enzymology. Human metabolic pathways. Structure, function and metabolism of carbohydrates including glycogen storage and gluconeogenesis. Restricted to students in Biochemistry specializations. Credit will be granted for only one of BIOC 202, BIOC 203 or BIOL 201. [3-0-1]
Prerequisite: All of BIOL 200, CHEM 203.
Corequisite: CHEM 213.
BIOC 301 (3) Biochemistry Laboratory
Techniques by which the chemical and physical properties of fundamental components of the cell are studied. [0-3-1]
Corequisite: One of BIOC 300, BIOC 302, BIOC 303.
BIOC 302 (3) General Biochemistry
Metabolic reactions of lipids, steroids, amino acids and nucleotides; the biochemistry of replication, transcription and translation. Credit will be granted for only one of BIOC 300, BIOC 302 or BIOC 303. [3-0-1]
Prerequisite: One of BIOL 201, BIOC 202, BIOC 203 and either (a) one of CHEM 204, CHEM 213 or (b) all of CHEM 205, CHEM 233 or (c) all of PHAR 220, CHEM 233.
BIOC 303 (6) Molecular Biochemistry
Structure, function and metabolism of lipids, steroids, amino acids and nucleotides; the biochemistry and molecular biology of replication, transcription, translation and gene regulation. For students in Biochemistry and Honours programs in other life sciences. Credit will be granted for only one of BIOC 300, BIOC 302 or BIOC 303. [3-0-0]
Prerequisite: One of BIOC 203, BIOL 201 and either (a) one of CHEM 204, CHEM 213 or (b) all of CHEM 205, CHEM 233.
BIOC 304 (3) Contemporary Biochemical Research
Exploration of the breadth and importance of biochemical research to present day challenges in medicine and biotechnology. Detailed experimental research case studies of novel biochemical methods used to address pressing and ongoing biochemical issues. [3-0-0]
Prerequisite: One of CHEM 213, CHEM 204.
Corequisite: BIOC 303.
BIOC 398 (3) Internship Work Placement I
Approved and supervised technical work experience in an industrial or academic laboratory for three or four months. Technical report required. Restricted to students admitted to the Internship Program in Biochemistry and Molecular Biology. This course is not eligible for Credit/D/Fail grading.
Prerequisite: Completion of academic third year in Biochemistry major or honours program is required.
BIOC 399 (3) Internship Work Placement II
Approved and supervised technical work experience in an industrial or academic research setting for four months. Technical report required. Restricted to students admitted to the Internship Program in Biochemistry and Molecular Biology. This course is not eligible for Credit/D/Fail grading.
Prerequisite: BIOC 398.
BIOC 402 (3) Proteins: Structure and Function
Structural components of proteins, classification by primary, secondary and tertiary structure, protein chemistry and purification, peptide and protein synthesis by chemical means and three-dimensional structure determination using X-ray diffraction and NMR. [3-0-0]
Prerequisite: One of BIOC 302, BIOC 303, BIOT 380. A minimum standing of 65% is recommended in these courses.
BIOC 403 (3) Enzymology
Kinetic analysis, catalytic mechanisms, transition state stabilization and regulation of activity, strategies for active site characterization and case studies of well-documented enzyme systems. Credit will be granted for only one of BIOC 403, CHEM 413 or CHEM 569. [3-0-0]
Prerequisite: BIOC 402. A minimum standing of 65% is recommended.
BIOC 404 (3) Biochemical Methods
Theory and application of classical and emerging technologies in biochemical research. Emphasis on using primary literature and oral presentation skills. Restricted to Honours students in Biochemistry or others with permission of the instructor. [1-0; 2-0]
BIOC 410 (3) Nucleic Acids-Structure and Function
Chemical, physical and biological properties of nucleic acids and their role in replication, transcription, translation and regulation of expression of genetic material. Credit will be granted for only one of BIOC 410 or BIOC 510. [3-0-0]
Prerequisite: Either (a) all of BIOC 303, BIOL 335 or (b) BIOT 380. A minimum standing of 65% is recommended in these courses.
BIOC 420 (3) Advanced Biochemical Techniques
Multi-week experiments in areas of contemporary biochemistry research using classical and modern techniques. Emphasis on experimental design, technique, critical analysis of data, and scientific communication skills. Restricted to Honours students in Biochemistry and others with permission of the instructor. [0-6-0]
Corequisite: BIOC 404.
BIOC 421 (3) Recombinant DNA Techniques
Multi-week experiments involving contemporary nucleic acid research, cloning and recombinant protein engineering. Emphasis is on experimental design, critical analysis of data and scientific communication skills. Restricted to Major students in Biochemistry. [0-6-0]
Prerequisite: All of BIOC 301, BIOC 410.
BIOC 440 (3) Concepts in Molecular Biology
Developing areas of molecular biology, focusing on experimental design and data analysis. Signal transduction, the use of model eukaryotes, and the regulation of gene expression. [3-0-0]
Prerequisite: One of BIOC 303, BIOT 380 and all of BIOC 402, BIOC 410.
BIOC 448 (3/6) c Directed Studies in Biochemistry
A library (3 credits) or a laboratory project with written report (3 or 6 credits) allowing a student to undertake an investigation on a specific topic as agreed upon by the faculty and student.
Prerequisite: Permission of the Department Head is required.
BIOC 449 (3/6) c Honours Thesis
A research problem under the direction of a faculty member. Restricted to Honours students.
BIOC 450 (3) Membrane Biochemistry
Biochemistry of membranes and membrane proteins, membrane fusion, electrical signaling, and the involvement of membrane proteins in disease and drug development. [3-0-0]
Prerequisite: One of BIOC 303, BIOT 380 and all of BIOC 402, BIOC 410.
BIOC 460 (3) Advanced Techniques in Biochemistry
Theoretical basis and practical applications of a selection of advanced techniques currently used in biochemical research. Topics will vary. [3-0-0]
Prerequisite: One of BIOC 303, BIOT 380 and all of BIOC 402, BIOC 410.
BIOC 490 (3) Student Directed Seminars
Self-directed, collaborative studies, in a group-learning environment, initiated and coordinated by senior undergraduate students with the supervision of a faculty advisor. Course structure, enrolment, and delivery methods will comply with the "Handbook for Student Directed Seminars". Not given every year. [3-0-0]
Prerequisite: Third-year standing.
Corequisite: One of BIOC 300, BIOC 302, BIOC 303.
BIOC 498 (3) Internship Work Placement III
Approved and supervised technical work experience in an industrial or academic research setting for four months. Technical report required. Restricted to students admitted to the Internship Program in Biochemistry and Molecular Biology. This course is not eligible for Credit/D/Fail grading.
Prerequisite: BIOC 399.
BIOC 499 (3) Internship Work Placement IV
Approved and supervised technical work experience in an industrial or academic research setting for four months. Technical report required. Restricted to students admitted to the Internship Program in Biochemistry and Molecular Biology. This course is not eligible for Credit/D/Fail grading.
Prerequisite: BIOC 498.
BIOC 501 (2-6) c Advanced Biochemistry Laboratory
Practical applications of advanced biochemical techniques. Admission is limited and is by permission of the department head. This course is not eligible for Credit/D/Fail grading.
Corequisite: BIOC 404.
BIOC 509 (3) Membrane Structure and Function
The physical properties and functional roles of lipids in membranes, liposomes, membrane permiability; membrane function; structure, biosynthesis and cell sorting of membrane proteins; and the structure-function relationships of channels, transporters and receptors. Given in alternate years. This course is not eligible for Credit/D/Fail grading. [3-0]
BIOC 510 (3) Nucleic Acids: Structure and Function
Structure and function of nucleic acids and their role in replication, transcription, translation and expression of genetic information. Credit will be granted for only one of BIOC 410 or BIOC 510. This course is not eligible for Credit/D/Fail grading. [3-0]
BIOC 511 (3) Biochemical Aspects of Cellular Regulation
A lecture and discussion course on the molecular basis of cellular regulation with special emphasis on mammalian cells. Mechanisms involved in the responses of cells to adrenergic, steroid and peptide hormones and growth factors. Regulation of the concentration and specific activity of key enzymes, transport systems and structural proteins. Given in alternate years. This course is not eligible for Credit/D/Fail grading. [3-0]
BIOC 514 (3) Advanced Topics in Protein Chemistry
Topics will include contemporary theoretical and experimental investigation of protein structure-function relationships. Topics will vary. Given in alternate years. This course is not eligible for Credit/D/Fail grading. [3-0]
BIOC 521 (3) Advanced Topics in Molecular Biology
Discussions based on topics in the current literature. This course is not eligible for Credit/D/Fail grading. [3-0]
Prerequisite: One of BIOC 410, BIOC 510.
BIOC 530 (3) Seminar in Biochemistry
Attendance is required of all graduate students in Biochemistry. Normally students will make a presentation once per year on a topic approved by their research advisor or committee or on the results of their research. This course is not eligible for Credit/D/Fail grading.
BIOC 548 (2-6) c Directed Studies
In special cases, with approval of the department head, advanced courses may be arranged for graduate students in attendance. This course is not eligible for Credit/D/Fail grading.
BIOC 549 (18) M.Sc. Thesis
This course is not eligible for Credit/D/Fail grading.
BIOC 649 (0) Doctoral Dissertation

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